The Ledger · treatment · topical

Tretinoin (topical retinoid)

Worth itfor adult hormonal acne
Evidence
High
Typical cost
~£12 / mo
Time to results
8–12 weeks
Access
Prescriber

Tretinoin is the closest thing adult acne has to a sure thing. It's a vitamin-A derivative that speeds up how fast your skin turns over, which clears the blockages that become breakouts and, over time, softens the marks they leave.

If you try one thing for breakouts skincare hasn't fixed, it's this. The catch is patience, not efficacy.

The trade-off is the first six weeks. Skin often gets drier, flakier, sometimes worse before it turns. Most people who quit tretinoin quit here, not because it failed but because nobody told them the dip was normal. Start twice a week, build up slowly, and it settles.

Where it sits against the alternatives

Ranked honestly against the other things people reach for. Same concern, different pathways.

treatmentAzelaic acidGentler, weaker. A good pairing, not a replacement.
naturalSpearmint teaMostly noise. Won't move deep hormonal acne.
naturalAt-home LED maskSkip it. Underdoses the wavelength that counts.

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Reviewed July 2026 · Sources: NICE CKS, Cochrane, AAD guidelines · Not yet clinically signed off